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KMID : 0981820100300040400
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Korean Journal of Laboratory Medicine
2010 Volume.30 No. 4 p.400 ~ p.405
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A Case of Disseminated Penicillium marneffei Infection in a Liver Transplant Recipient
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Seo Ja-Young
Ma Young-Eun
Lee Jang-Ho
Lee Seung-Tae
Ki Chang-Seok
Lee Nam-Yong
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Abstract
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Penicillium marneffei is the only dimorphic fungus among Penicillium spp. that can cause a fatal infection in immunocompromised patients. P. marneffei is endemic in Southeast Asia and eastern China. P. marneffei infection is an AIDS-defining illness and the third most common opportunistic infection in the endemic regions. Here, the authors report a case of disseminated P. marneffei infection in a patient who underwent liver transplantation in China. During the hospital stay, the mold form of the fungus that produced a red wine-colored pigment on the agar plate was isolated from the patient’s urine, transtracheal aspirate, and blood. The fungus was identified as P. marneffei by direct sequencing of the D1-D2 and ITS regions. Thermal dimorphism was also confirmed by subculturing the colony at 37℃. To the best of our knowledge, this is the first Korean case of disseminated P. marneffei infection in a liver transplant recipient.
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KEYWORD
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Penicillium marneffei, Dimorphic fungus, Disseminated infection, Liver transplantation
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